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BET inhibitor has lasting effects in AML, MM
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CHICAGO—A BET inhibitor can have potent and long-lasting effects against leukemia and multiple myeloma (MM), according to researchers. The...
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Study reveals gene variants that predispose kids to ALL
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Germline variants in IKZF1 can predispose carriers to acute lymphoblastic leukemia (ALL), according to a study published in Cancer Cell. The...
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Inhibitor outperforms rivals in leukemia, lymphoma
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CHICAGO—Preclinical research suggests the pan-FLT3/pan-BTK inhibitor CG’806 is more effective than other kinase inhibitors in fighting certain...
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Team uses iPSCs to create ‘universal’ CAR T cells
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CHICAGO—Researchers have used induced pluripotent stem cells (iPSCs) to create a “universal” chimeric antigen receptor (CAR) T-cell therapy known...
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Groups launch open portal for cancer models
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The European Bioinformatics Institute (EMBL-EBI) and The Jackson Laboratory (JAX) have developed an open cancer research portal for patient-...
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Gene therapy exceeds expectations in β-thalassemia
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The gene therapy LentiGlobin can reduce or eliminate transfusion dependence in patients with β-thalassemia, according to a pair of phase 1/2...
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Idarucizumab receives full FDA approval
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The US Food and Drug Administration (FDA) has granted full approval to idarucizumab (Praxbind®), the specific reversal agent for dabigatran...
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Antibody has ‘potent’ effects against AML
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CHICAGO—The bispecific antibody APVO436 has demonstrated robust T-cell activation with limited cytokine release in acute myeloid leukemia (AML),...
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Fostamatinib approved to treat adults with chronic ITP
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The US Food and Drug Administration (FDA) has granted approval for the oral SYK inhibitor fostamatinib disodium hexahydrate (Tavalisse™)....
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FDA expands approved use of product for VWD
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The US Food and Drug Administration (FDA) has expanded the approved use of Vonvendi, a recombinant von Willebrand factor product. Vonvendi is now...
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Emicizumab receives breakthrough designation
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The US Food and Drug Administration (FDA) has granted breakthrough therapy designation to emicizumab (Hemlibra®) for patients who have hemophilia...
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Generic melphalan available in US
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Fresenius Kabi’s Melphalan Hydrochloride for Injection, a generic version of Alkeran®, is now available in the US. Melphalan Hydrochloride for...
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Drug appears to aid chemo in AML
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Adding an experimental compound to chemotherapy is a “promising” treatment approach for certain patients with acute myeloid leukemia (AML),...
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Team modifies platelets to improve coagulation
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Researchers say they have found a way to improve the coagulability of platelets—by loading them with thrombin encapsulated in liposomes....
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FDA lifts hold on trials of BPX-501
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- HT Staff
The US Food and Drug Administration (FDA) has lifted the clinical hold on studies of BPX-501 in the US. BPX-501 is an adjunct T-cell therapy...