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AGA Clinical Practice Update: Expert review on personalizing GERD management
The document includes new advice on use of upfront objective testing for isolated extraesophageal symptoms.
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AGA Clinical Practice Update: Expert review on deprescribing PPIs
Fear of adverse events often drive interest in de-escalating or stopping PPIs, but many fears are unfounded.
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Nanoparticle shows promise for ALS
A phase 2 study revealed a significant survival advantage with drug that targets mitochondria.
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Antiseizure medication appears safe in pregnancy
Verbal scores at age 3 were similar among children of mothers with or without epilepsy.
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IBD: Patients struggle with presenteeism, mental health
A prospective study found higher rates of anxiety and depression and reduced work productivity.
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Gene therapy demonstrates modest success in genetic blindness
‘First step’ toward improvement in Leber hereditary optic neuropathy is maintained out to 4 years.
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Cardiac monitoring suggested for advanced RCC patients with high troponin T levels after combo treatment
Troponin T levels may help determine who is at most risk of cardiovascular events after receiving immune checkpoint and VEGF inhibitors.
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Two leading oral cancer treatment guidelines differ on recurrence and survival predictions
CAP guidance predicted recurrence and survival, but RCPath guidance did not.
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Immunotherapy treatment shows promise for resectable liver cancer
Positive phase 2 results pave the way for phase 3 studies.
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Rise in oral cancers among young nonsmokers points to immunodeficiency
A study of 2,073 patients shows nonsmokers have higher mortality rates compared with smokers.
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Breast density linked to familial breast cancer risk
Findings underscore the need for mammograms early in high risk premenopausal women.
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Trial gives new guidance for choosing initial PsA treatment
Adding the tumor necrosis factor inhibitor adalimumab to methotrexate because of a lack of efficacy or tolerability produced better results than...
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Untargeted CT scans leads to overdiagnoses in lung cancer
The dangers of overdiagnosis are counterintuitive, but real.
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Topical steroid shows promise for EOE
Formulation designed for the esophagus could replace repurposed inhalants in eosinophilic esophagitis.
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B-cell depletion overkill?
B-cell depletion following ocrelizumab or rituximab treatment often lasts longer than 6 months.