Article
75-year-old man • fatigue • unintentional weight loss • anemia • Dx?
► Fatigue
► Unintentional weight loss
► Anemia
Article
Does XR injectable naltrexone prevent relapse as effectively as daily sublingual buprenorphine-naloxone?
EVIDENCE-BASED ANSWER: Yes. Monthly extended-release injectable naltrexone (XR-NTX) treats opioid use disorder as effectively as daily sublingual...
Article
Which oral nonopioid agents are most effective for OA pain?
EVIDENCE-BASED ANSWER: Nonsteroidal anti-inflammatory drugs (NSAIDs), when used at the maximum clinically effective dose, reduce osteoarthritis (...
Article
How often does long-term PPI therapy cause clinically significant hypomagnesemia?
EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory...
Article
What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events?
EVIDENCE-BASED ANSWER: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years (...
Article
What is the best beta-blocker for systolic heart failure?
EVIDENCE-BASED ANSWER: Three beta-blockers—carvedilol, metoprolol succinate, and bisoprolol—reduce mortality equally (by about 30% over one year)...
Article
Does surgery relieve the pain of a herniated disc?
EVIDENCE-BASED ANSWER: YES, in the short term. Patients with an acute episode of low back pain, radicular symptoms, and evidence of a herniated...
Article
Should you evaluate for CAD in seniors with premature ventricular contractions?
EVIDENCE-BASED ANSWER: Yes. Current guidelines suggest evaluating patients with premature ventricular contractions (PVCs) and associated risk...
Article
Is the long-term use of proton pump inhibitors safe?
EVIDENCE-BASED ANSWER: Long-term use of proton pump inhibitors (PPIs) appears safe, resulting in no clinically relevant adverse effects (strength...
Article
Should we discontinue Pap smear screening in women aged >65 years?
EVIDENCE-BASED ANSWER: Women with a history of regular, normal Pap smear screening should discontinue screening by age 65 years (strength of...
Article
What is the best hypnotic for use in the elderly?
EVIDENCE-BASED ANSWER: Short-acting hypnotics such as zolpidem (Ambien) or zaleplon (Sonata) are the preferred hypnotics in the elderly because of...
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What regimens eradicate Heliobacter pylori?
EVIDENCE-BASED ANSWER: Fourteen-day triple therapy with a proton pump inhibitor (PPI) plus clarithromycin and either amoxicillin or metronidazole...