Lung Cancer
From the Journals
Despite benefits, extended-interval pembro uptake remains low
It’s possible that low uptake could stem from clinicians’ doubts about switching to an extended-interval dose, given that the FDA’s approval was...
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Weight gain linked to cancer survival in men and women
The finding underscores the need for nutritional support emphasized in 2020 ASCO guidelines.
Conference Coverage
High BMI linked to better survival for cancer patients treated with ICI, but for men only
The reasons behind the findings and implications for treatment are unknown, as is whether it applies to patients with specific cancers.
Conference Coverage
Sotorasib superior to docetaxel in KRAS G12C–mutated NSCLC
In its first randomized, phase 3 comparison trial, the first-in-class agent sotorasib held its own against the standard of care docetaxel.
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Atezolizumab doubles survival of NSCLC patients with poor performance status
Patients typically excluded from clinical trials because of age or comorbidities had better survival with atezolizumab than single-agent...
From the Journals
Opioids after lung cancer surgery may up all-cause mortality risk
“New long-term opioid use may be associated with poor long-term survival outcomes, especially in potent opioid users.”
Conference Coverage
In NSCLC, not all EGFR mutations are the same
Patients with the Ex20 insertion may buck trend by responding well to ICIs.
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In early NSCLC, comorbidities linked to survival
Respiratory and cardiometabolic comorbidities were associated with significantly worse overall survival in lung cancer.
Conference Coverage
‘Smoking gun–level’ evidence found linking air pollution with lung cancer
The finding could lead to strategies for preventing lung cancer in nonsmokers exposed to high levels of foul air.
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Gene mutations may drive lung cancer in never-smokers
Study hints at mechanistic differences between small cell lung cancer in smokers versus nonsmokers.