Clinical Inquiries
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Clinical Inquiries
Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis?
EVIDENCE-BASED ANSWER: No direct evidence suggests glucosamine or chrondroitin cause regeneration of cartilage in osteoarthritis. Use of...
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Clinical Inquiries
Does microalbuminuria screening in diabetes prevent complications?
EVIDENCE-BASED ANSWER: Screening diabetic patients for microalbuminuria identifies those who may benefit from treatments that delay progression to...
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Clinical Inquiries
Is MRI useful for evaluation of acute low back pain?
EVIDENCE-BASED ANSWER: Magnetic resonance imaging (MRI) is rarely helpful in the evaluation of acute low back pain. Limited evidence suggests...
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Clinical Inquiries
Do calcium supplements prevent postmenopausal osteoporotic fractures?
EVIDENCE-BASED ANSWER: Calcium supplementation (1000–1200 mg daily) decreases menopause-related bone loss and reduces the rate of vertebral and...
Applied Evidence
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Applied Evidence
Achieving the best outcome in treatment of depression
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Applied Evidence
Diagnosing skin malignancy: Assessment of predictive clinical criteria and risk factors
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Applied Evidence
Gastroesophageal Reflux Disease
Commentary
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Commentary
You’ve spoken, and we hear you
Original Research
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Original Research
After-hours telephone triage affects patient safety
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Original Research
Patient safety after hours: Time for action
Photo Rounds
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Photo Rounds
Recognition of skin cancer patterns
Q&A
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Q&A
Is topical nifedipine effective for chronic anal fissures?
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Q&A
Is permethrin 5% cream effective for rosacea?
BACKGROUND: The skin mite D folliculorum has been implicated as a cause of rosacea. However, other possible causes include a genetic...
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Q&A
What are the risks of long-term NSAIDs and COX-2 inhibitors?
BACKGROUND: Much of the widespread use of COX-2 inhibitors is due to the perception that they are safer than traditional NSAIDs.
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Q&A
Is imiquimod effective and safe for treatment of actinic keratosis?
BACKGROUND: Actinic keratosis is a precancerous skin lesion commonly found on areas frequently exposed to the sun. Among aging Americans, these...
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Q&A
Does acetaminophen affect liver function in alcoholic patients?
BACKGROUND: Traditionally, acetaminophen use in alcoholics has been discouraged due to uncontrolled retrospective data (mostly case reports) that...
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Q&A
Are diuretics helpful in acute renal failure?
BACKGROUND: Diuretics continue to be widely used for treating acute renal failure despite the lack of supporting evidence.
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Q&A
Is rate control better than rhythm control for atrial fibrillation in older high-risk patients?
BACKGROUND: The goal for managing high-risk patients who have atrial fibrillation traditionally has been to achieve and maintain normal sinus...
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Q&A
Are ionized wrist bracelets better than placebo for musculoskeletal pain?
BACKGROUND: Currently, there are advertisements claiming that this ionized bracelet relieves musculoskeletal pain.
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Q&A
Does magnesium therapy early in acute MI reduce mortality?
BACKGROUND: Research is conflicting regarding the usefulness of magnesium therapy in patients with acute MI. An early study of 2316 patients and a...
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Q&A
Oral vitamin D3 decreases fracture risk in the elderly
BACKGROUND: Previous studies have shown that daily supplementation with vitamin D3 (800 IU) and calcium decreases the incidence of fractures;...
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Q&A
Is terazosin helpful in chronic prostatitis?
BACKGROUND: Lifetime prevalence of chronic prostatitis in men aged 40 to 79 years is 5%, resulting in significant morbidity, unnecessary...
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Q&A
Does C-reactive protein predict cardiovascular events in women better than LDL?
BACKGROUND: A growing body of evidence suggests an important role for inflammation in cardiovascular disease. Nested case-control studies have...