Clinical Inquiries
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Clinical Inquiries
What is the target for low-density lipoprotein cholesterol in patients with heart disease?
EVIDENCE-BASED ANSWER: Large published randomized controlled trials (RCTs) show that pravastatin and simvastatin are well-tolerated and reduce...
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Clinical Inquiries
What are the most effective interventions to reduce childhood obesity?
EVIDENCE-BASED ANSWER: Efforts to increase physical activity or decrease sedentary activities have shown some short-term benefit, and adding...
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Clinical Inquiries
What medications are effective for treating symptoms of premenstrual syndrome (PMS)?
EVIDENCE-BASED ANSWER: Vitamin B6 (50–100 mg/d) and elemental calcium (1200 mg/d) are safe, inexpensive, and moderately effective (Table) (grade...
Applied Evidence
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Applied Evidence
Prevention and Treatment of Osteoporosis in Postmenopausal Women
The goals of therapy for osteoporosis are fracture prevention and pain relief; prior fracture is associated with a fivefold risk of future...
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Applied Evidence
Evaluation and treatment of the patient with allergic rhinitis
Commentary
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Commentary
Effectiveness of sibutramine
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Commentary
Effectiveness and safety of lidocaine patch 5%
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Commentary
The time is right to unite
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Commentary
Snake oil or sound medicine
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Commentary
Electronic solutions to implementing lipid guidelines
Q&A
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Q&A
Arthroscopic surgery ineffective for osteoarthritis of the knee
Moseley JB, O’Malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347:81–8...
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Q&A
DEET is the most effective mosquito repellent
Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med 2002; 347:13–8.
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Q&A
Topical steroids more effective than antifungals for chronic paronychia
Tosti A, Piraccini BM, Ghetti E, Colombo MD. Topical steroids versus systemic antifungals in the treatment of chronic paronychia: an open,...
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Q&A
Antioxidants do not prevent heart disease in high-risk individuals
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomized placebo-controlled trial....
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Q&A
β-Blocker survival benefit outweighs side-effect risks
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker therapy and symptoms of depression, fatigue and sexual dysfunction....
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Q&A
B-type natriuretic peptide is an accurate predictor of heart failure in the emergency department
Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J...
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Q&A
Hair apposition technique is better than suturing scalp lacerations
Hock MO, Ooi SB, Saw SM, Lim SH. A randomized controlled trial comparing the hair apposition technique with tissue glue to standard suturing in...
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Q&A
Do the risks of estrogen plus progestin outweigh the benefits in healthy post-menopausal women?
Risks and benefits of estrogen plus progestin in healthy post-menopausal women: principal results from the Women’s Health Initiative randomized...
Original Research
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Original Research
Improving influenza vaccination rates in the elderly
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Original Research
Information about tests for breast cancer: What are we telling people?
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Original Research
Is a history of trauma associated with a reduced likelihood of cervical cancer screening?
OBJECTIVE: We tested the hypothesis that a history of trauma (especially sexual trauma) was associated with a reduced likelihood of having had...
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Original Research
Relationships between physician practice style, patient satisfaction, and attributes of primary care
OBJECTIVE: Style of physician-patient interaction has been shown to have an impact on patient outcomes. Although many different interaction styles...
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Original Research
Do written action plans improve patient outcomes in asthma? An evidence-based analysis
OBJECTIVE: Current guidelines recommend use of written action plans and peak flow monitoring as key components of asthma care.
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Original Research
Management of the low-grade abnormal Pap smear: What are women’s preferences?
OBJECTIVE: To evaluate preferences among ethnically diverse women for the management of a low-grade abnormal Pap smear result: early colposcopy or...
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Original Research
Cancer risk assessment from family history: Gaps in primary care practice