Applied Evidence

B₁₂ deficiency: A look beyond pernicious anemia

Author:

Emmanuel Andrès, MD

Josep Vidal-Alaball, MD

Noureddine Henoun Loukili, PhD, JA

Food-B12 malabsorption—not pernicious anemia—is the leading cause of B12 malabsorption. It’s also very subtle.

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Applied Evidence

Syncope in athletes: A guide to getting them back on their feet

Author:

Sumit Verma, MD

Fainting during exercise may be a life-threatening sign; cardiologic and neurologic testing help guide treatment.

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Clinical Inquiries

When should you treat scabies empirically?

Author:

Tanya L. Page, MD

Patrice M. Eiff, MD

Dolores Zegar Judkins, MLS

EVIDENCE-BASED ANSWER: Empirically treat patients when they have pruritus and lesions typical of scabies in at least 2 places—even if there is no...

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Clinical Inquiries

What is the best way to evaluate secondary infertility?

Author:

Charles H. Davis, III, MD

Mary N. Hall, MD

Leonora Kaufmann, MLIS

EVIDENCE-BASED ANSWER: The work-up for secondary infertility—the inability to conceive after 1 year of regular unprotected intercourse for a...

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Clinical Inquiries

What are the best treatments for herpes labialis?

Author:

Taehee Chon, MD

Loan Nguyen, MLS

EVIDENCE-BASED ANSWER: There are 3: valacyclovir, acyclovir, and topical penciclovir. Valacyclovir, 2 g twice in 1 day taken during the prodromal...

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Clinical Inquiries

What’s the best way to screen for anxiety and panic disorders?

Author:

John D. Hallgren, MD

Jacquelyn R. Morton, MLS

EVIDENCE-BASED ANSWER: The GAD-7 has the best evidence and utility in the primary care setting for generalized anxiety disorder (strength of...

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Clinical Inquiries

Which oral antifungal is best for toenail onychomycosis?

Author:

Jose R. Hinojosa, MD

Kristin Hitchcock, MSI

EVIDENCE-BASED ANSWER: Terbinafine, 250 mg taken daily for 12 weeks, is the best regimen for toenail onychomycosis due to better clinical and...

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Clinical Inquiries

Does a low-fat diet help prevent breast cancer?

Author:

Elizabeth Steiner, MD

David Klubert, MD

Meg Hayes, MD

Andrew Hamilton, MS, MLS

EVIDENCE-BASED ANSWER: No. Studies show no evidence that reducing dietary fat decreases a woman’s risk of developing postmenopausal breast cancer...

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Commentary

“Should I have a mammogram?” Handout helps women decide

Author:

David L. Hahn, MD, MS

The ACP urges us to discuss mammography with women in their 40s. This handout can help.

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Photo Rounds

A young girl with blisters on her forehead

Author:

Khashayar Sarabi, MD

Abdulhafez Selim, MD, PhD

Amor Khachemoune, MD, CWS

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