Applied Evidence

Statins and elevated liver tests: What’s the fuss?

Author:

Edward Onusko, MD

Even when liver function tests are moderately elevated, statins are safe for most patients

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Applied Evidence

Benign prostatic hyperplasia: Treat or wait?

Author:

John H. Davidson, MD

Questionnaire with "bother score" can help you decide.

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Clinical Inquiries

What are the most effective ways you can help patients stop smoking?

Author:

Zille Huma Shah, MD

Shobha Rao, MD

Helen G. Mayo, MLS

EVIDENCE-BASED ANSWER: Brief counseling, nicotine replacement therapy, antidepressants, and varenicline all work well. Physician intervention...

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Clinical Inquiries

Does antepartum perineal massage reduce intrapartum lacerations?

Author:

John Dame, MD

Jon Neher, MD

Sarah Safranek, MLIS

EVIDENCE-BASED ANSWER: Yes—to a point. Antepartum perineal massage reduces both the incidence of perineal trauma requiring suturing and the...

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Clinical Inquiries

What is the best way to screen for breast cancer in women with implants?

Author:

Patricia Goodemote, MD

Deana Mitchell, DO

William Nichols, MLS

EVIDENCE-BASED ANSWER: Mammography is best. It is considered as effective for screening women who have undergone augmentation mammoplasty as those...

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Clinical Inquiries

What is the best treatment for oral thrush in healthy infants?

Author:

Cindy W. Su, MD

Sean Gaskie, MD

Barbara Jamieson, MLS

EVIDENCE-BASED ANSWER: Nystatin oral suspension is a safe first-line therapy; fluconazole is more effective (strength of recommendation [SOR]: B,...

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Clinical Inquiries

Does regular exercise reduce the pain and stiffness of osteoarthritis?

Author:

Jason Blackham, MD

Joseph P. Garry, MD

Doyle M. Cummings, PharmD

Roger G. Russell, MLS

EVIDENCE-BASED ANSWER: Yes, moderately. Exercise helps reduce the pain, but it’s unclear whether it helps with stiffness. Exercise moderately...

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Commentary

ENHANCE study: Ezetimibe lowers LDL, but does it matter?

Author:

James Stevermer, MD, MSPH

We cannot be sure of clinical benefits until the ongoing trial reports the patient-oriented outcomes.

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Commentary

FluMist: Refrigerated, never frozen

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Commentary

A better staging system for pressure ulcers

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Photo Rounds

Tender growth on toe

Author:

Maheshwari Ramineni, MBBS

Michael Sonabend, MD, resident

Rajani Katta, MD

Trauma preceded the development of this growth; antibiotics failed to treat it when it oozed.

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PURLs

Patients insist on antibiotics for sinusitis? Here is a good reason to say “no”

Author:

Sarah-Anne Schumann, MD

John Hickner, MD, MSc

Bernard Ewigman, MD, MSPH

Convincing evidence emerges from primary care trials.

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