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Migraine negatively correlates with large artery atherosclerosis in ischemic stroke


Key clinical point: Migraine, migraine with aura (MWA), and migraine without aura (MWoA) are negatively associated with large artery atherosclerosis (LAA) in young patients with ischemic stroke, irrespective of traditional vascular risk factors.

Major finding: LAA of any grade was significantly less frequent in patients with migraine ( P < .001), MWA ( P < .001), and MWoA ( P = .005) vs. those without migraine. Migraine (adjusted odds ratio [aOR] 0.44; P = .005), MWoA (aOR 0.42; P = .020), and MWA (aOR 0.47; P = .037) vs. no migraine showed a negative association with LAA of any grade.

Study details: Findings are from a cross-sectional study including 415 patients aged 18-54 years with first-ever acute ischemic stroke, of which 144 had migraine (MWA, n = 76; MWoA, n = 68).

Disclosures: No funding was received for this study. The authors declared no conflicts of interest.

Source: Gollion C et al. Headache. 2022;62(2):191-7 (Feb 5). Doi: 10.1111/head.14265

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