A 16-year-old female patient presents with shortness of breath. She does not have a history of allergies but has nasal polyps. After being hospitalized three times over the course of a year, she was started on a regimen of high-dose inhaled corticosteroids and a long-acting bronchodilator; she reports that she is adherent with these medications. The blood eosinophil count is 160 cells/μL.