Combination Treatment using Platelet-Rich Plasma and an Angiotensin II Receptor Blocker for Muscle Contusions

SAN FRANCISCO— A separate, animal study looked at the potential effects of Platelet-Rich Plasma (PRP), in combination with hypertension and heart drug Losartan, in treating muscle contusions (bruises) in mice. While most contusions are minor and heal quickly, more severe cases can lead to serious complications. Building on initial evidence that PRP can accelerate muscle healing after injury, this study explored the possible advantages of using Losartan (an established drug commonly used to treat hypertension and to avoid complications following congestive heart failure) in combination with PRP. When used 3 days after surgery, Losartan has also been proven to promote functional improvement and muscle regeneration, and decrease scarring.

The study involved 40 mice with injured lower leg muscles. Some were given PRP alone; some, Losartan alone (proven to promote functional improvement, regenerate muscles and decrease scarring). Ten mice received PRP and Losartan. At 4 weeks post injury, the mice that received the combination PRP and Losartan treatment showed improved muscle strength, enhanced muscle regeneration, greater angiogenesis (growth of new blood vessels), and decreased scarring.

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