Key clinical point: In patients with early-stage breast cancer (BC), breast conserving surgery with radiotherapy (BCT) provided a significant survival advantage over total mastectomy (TM) without increasing the rates of locoregional recurrence.
Major finding: BCT vs TM improved overall survival by 37% (hazard ratio [HR] 1.37; P < .001) and BC-specific survival by 49% (HR 1.49; P < .001), with rates of locoregional recurrence ( P > .9) being comparable between the groups.
Study details: This study analyzed the data of 12,456 patients with pT1-2 pN0 BC from a prospectively maintained database, of which 8422 and 4034 patients underwent BCT and TM, respectively.
Disclosures: This study did not report the source of funding. The authors did not report any conflicts of interest.
Source: Vasilyeva E et al. Breast conserving surgery combined with radiation therapy offers improved survival over mastectomy in early-stage breast cancer. Am J Surg. 2023 (May 22). doi: 10.1016/j.amjsurg.2023.05.005