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Airways disorders


Updated guidelines on the use of home O2 in COPD: A much-needed respite

Dr. Kadambari Vijaykumar

Dr. Kadambari Vijaykumar

The use of long-term oxygen therapy (LTOT, oxygen prescribed for at least 15 h/day) in patients with COPD and chronic hypoxemia has been standard of care based on trials from the 1980s that conferred a survival benefit with the use of continuous oxygen (Ann Internal Med. 1980;93[3]:391-8). More recently, LTOT has not shown to improve survival or delay time to the hospitalization in patients with stable COPD and resting or exercise-induced moderate desaturation (N Engl J Med. 2016;375[17]:1617-27). Thus far, existing recommendations had been semi-inclusive in patient selection. A fundamental lack of evidence-based clinical practice guidelines prompted additional research into patient selection, portable oxygen technology, advocacy for improved oxygen therapy financing, and updating of policies (Jacobs et al., Ann Am Thorac Soc. 2018;15[12]:1369-81). With over a million patients in the United States being prescribed home oxygen and reported disconnect in-home oxygen needs/experiences across disease processes, lifestyles, and oxygen supply requirements, the 2020 American Thoracic Society (ATS) workshop on optimizing home oxygen therapy sought to answer critical questions in the use of LTOT for COPD patients (AlMutairi, et al. Respir Care. 2018;63[11]:1321-30; Jacobs, et al. Am J Respir Crit Care Med. 2020;202[10]:e121-e141).

Dr. Dharani Kumari Narendra

Dr. Dharani Kumari Narendra

Based on a thorough systematic review of available literature, the committee made strong recommendations (moderate-quality evidence) for LTOT use in COPD with severe chronic resting hypoxemia (PaO2 ≤ 55 mm Hg or SpO2 ≤ 88%), conditional recommendations for the following: (1) Against LTOT use in COPD with moderate chronic resting hypoxemia [SpO2 89%-93% (low-quality evidence)]; (2) Ambulatory oxygen use in adults with COPD with severe exertional hypoxemia (moderate-quality evidence); and (3) Liquid oxygen use in patients who are mobile outside the home and require >3 L/min of continuous-flow oxygen during exertion (very-low-quality evidence). The review identified a dire need to develop a more robust evidence-based practice and incorporate shared decision-making while highlighting the deficit of conclusive data supporting supplemental oxygen for patients with exertional desaturation.

Kadambari Vijaykumar, MD
Fellow-in-Training Member

Dharani Kumari Narendra, MBBS, FCCP
Steering Committee Member

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