Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Nicotine Replacement Therapy in Smokers with CHD
J Am Heart Assoc; ePub 2018 Sep 7; Pack, et al
The use of nicotine replacement therapy (NRT) was not associated with any differences in short-term outcomes among smokers hospitalized for treatment of coronary heart disease (CHD), a recent study found. Researchers examined the short-term safety of NRT in a geographically and structurally diverse sample of US hospitals in 2014. They compared smokers who started NRT in the first 2 days of hospitalization with smokers without any exposure to NRT. Outcomes included inpatient mortality, hospital length of stay (LOS), and 1-month readmission. Among the findings:
- From 270 hospitals, 27,459 smokers (mean age 58 years, 69% men, 56.9% in ICU) were included, of whom 4,885 (17.8%) received NRT.
- Among patients with myocardial infarction, those who received NRT showed no difference in mortality, mean LOS, or 1-month readmission, when compared with patients who did not receive NRT.
- Results were similar for patients undergoing percutaneous coronary intervention or coronary artery bypass surgery.
- NRT is a safe and reasonable treatment option in treating nicotine withdrawal.
Pack QR, Priya A, Lagu TC, et al. Short-term safety of nicotine replacement in smokers hospitalized with coronary heart disease. [Published online ahead of print September 7, 2018]. J Am Heart Assoc. doi:10.1161/JAHA.118.009424.
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Acute Illness and Cannabis Use in Adults, Ann Intern Med; ePub 2019 Mar 26; Monte, et al
Dual Receipt of Rx Opioids & Overdose Death, Ann Intern Med; ePub 2019 Mar 12; Moyo, et al
Opioid-Related Mortality in US by Opioid Type, JAMA Netw Open; 2019 Feb 22; Kiang, et al
Disparities in the Prescription of Opioids, JAMA Intern Med; ePub 2019 Feb 11; Friedman, et al
Prevention of Prescription Opioid Misuse in the US, JAMA Netw Open; 2019 Feb 1; Chen, et al