Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Assessing the HCV Care Cascade in Baby Boomers
Am J Manag Care; 2018 Sep; Brady, Vellozzi, et al
Initiating hepatitis C virus (HCV) treatment was the largest gap in the HCV care cascade among persons born between 1945 and 1965, although linkage to care was largely successful in this target birth cohort, a new study found. Researchers conducted chart reviews of patients with a new positive HCV antibody test at 3 academic medical centers participating in the Birth-Cohort Evaluation to Advance Screening and Testing of Hepatitis C (BEST-C) study. They tracked receipt of RNA testing, clinical evaluation, treatment initiation, and treatment completion among participants born between 1945-1965 who were newly diagnosed as HCV antibody-positive between December 2012 and October 2015. They found:
- Of 130 HCV-seropositive individuals, 118 (91%) had an RNA or genotype test, 75 (58%) were RNA-positive, and 73 (56%) were linked to care.
- However, only 22 (17% overall, 29% among RNA-positive) started treatment and 21 (16%; 28% among RNA-positive) completed treatment.
Brady JE, Vellozzi C, Hariri S, et al. Hepatitis C care cascade among persons born 1945-1965: 3 medical centers. Am J Manag Care. 2018;24(9):421-427.
This Week's Must Reads
Must Reads in Hepatitis
Glecaprevir/Pibrentasvir Efficacy & Safety Assessed, J Hepatol; ePub 2018 Nov 23; D’Ambrosio, et al
HCV Infection Among Children & Young Persons, J Hepatol; ePub 2018 Nov 26; Modin, et al
HCV Patients with Limited Access to Antiviral Therapy, Dig Liver Dis; ePub 2018 Nov 29; Lens, et al
Progression in the Elimination of HCV Infection, PLoS One; ePub 2018 Dec 4; Juanbeltz, et al
Increased HCV Screening in Veteran Populations, Jt Comm J Qual Patient Saf; ePub 2018 Sep 25; Wray, et al