ALL
Conference Coverage
ASH studies look at racial disparities in ALL care, outcomes
Findings of two studies on U.S. blood cancer care suggest that “structural racism” may play a role in worse outcomes among young Hispanic and...
Conference Coverage
TKI/BiTE combo extends survival of older patients with Ph+ALL
In these elderly patients who are not candidates for chemo, the issue is whether we can prolong remission by the addition of other treatments,...
Conference Coverage
For leukemias, COVID-19 death risks tied to poor prognoses, ICU deferrals
COVID-19 death risks for acute leukemias were driven by poor physician-assessed prognoses and opting out of recommended ICU care.
From the Journals
Customizing pre-CAR T chemotherapy could improve ALL patient outcomes
Findings suggest a way to reduce relapses in patients undergoing CAR T-cell therapy: Tailor pre-CAR T lymphodepleting therapy.
From the Journals
Treating ALL: Asparaginase enzyme levels linked to toxicities
New data suggest benefits of drug monitoring to assess risks for pancreatitis and other toxicities.
From the Journals
Immunotherapies for children with r/r ALL face off
Outcomes were better with tisagenlecleucel vs. blinatumomab in an indirect comparison, but clinical indications should determine which agent to...
Latest News
New trials in leukemia: Could your patient benefit?
Late-phase trials are opening up for leukemia patients aged 1-65 years.
From the Journals
Tolerability doesn’t explain why kids do better than adults on ALL regimens
Differences in tumor biology seem to be at play.
From the Journals
CAR T for ALL: Areas that need optimizing
CAR T-cell therapy optimization is needed in a range of key areas.
News from the FDA/CDC
FDA approves first CAR T-cell for adult ALL: For patients with R/R B-cell disease
“This is a meaningful advance because roughly half of all adults with B-ALL will relapse on currently available therapies.”
From the Journals
Methylation patterns correlate with prognosis in children with T-ALL
Hypomethylation of the asparagine synthase gene was significantly associated with poor therapeutic outcome in children with T-cell acute...