Key clinical point: Preoperative D-dimer-to-albumin ratio (DAR) serves as an independent predictive marker for long-term prognosis in patients with gastric cancer.
Major finding: The low-DAR vs high-DAR group had significantly higher overall survival (OS; 63.8% vs 44.2%; P < .001) and recurrence-free survival (RFS; 62.4% vs 46.6%; P < .001) rates. The preoperative DAR was an independent risk factor for OS (training cohort: adjusted hazard ratio [aHR] 1.47; P < .001; testing cohort: aHR 1.50; P = .014) and RFS (training cohort: aHR 1.43; P < .001; testing cohort: aHR 1.59; P = .006).
Study details: This retrospective study included 1766 patients with gastric cancer who underwent gastrectomy (training cohort n = 1236; testing cohort n = 530) and were categorized into the high-DAR (>0.0145) or low-DAR (≤0.0145) group.
Disclosures: No information on the source of funding was provided. The authors declared no conflicts of interest.
Source: Lin GS et al. Value of the preoperative D-dimer to albumin ratio for survival and recurrence patterns in gastric cancer. Ann Surg Oncol. 2022 (Oct 25). Doi: 10.1245/s10434-022-12625-7