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Substantial Contributor to Pediatric NHL Burden
Cancer; ePub 2017 Jul 31; Yanik, Shiels, et al
Among children and adolescents, solid organ transplant recipients are responsible for a large share of non-Hodgkin lymphoma (NHL) diagnoses, according to a cohort study involving more than 22,000 individuals. Investigators calculated cancer incidence rates of people aged <20 years in the transplant and general populations, and estimated pediatric NHL counts. Among the results:
- ~3% of pediatric NHL diagnoses in the general population occurred in transplant recipients.
- Among transplant recipients, diffuse large B-cell lymphoma (DLBCL) occurred in nearly two-thirds of patients; Burkitt lymphoma (BL) occurred in 9%.
- For DLBCL, transplant recipients contributed 8% of diagnoses.
- For BL, transplant recipients contributed to <1% of such.
- The largest proportion of NHLs occurred in children aged <5 years and in more recent calendar years (~4% in each subgroup).
- DLBCL patterns were similar: transplant recipients contributed 20% of cases among children aged <5 years and 11% of cases in more recent years.
Citation:
Yanik E, Shiels M, Smith J, et al. Contribution of solid organ transplant recipients to the pediatric non-Hodgkin lymphoma burden in the United States. [Published online ahead of print July 31, 2017]. Cancer. doi:10.1002/cncr.30923.