Key clinical point: Including time to recurrence, gender, and distant recurrence into risk stratification tools may aid in patient counseling and decision making regarding type and regimen of salvage treatment.

Major finding: In patients who undergo nephrectomy for localized renal cell carcinoma, shorter time to recurrence (P= 0.0008), female gender (P=0.035), and distant vs. local recurrence location (P less than 0.0001) were independently associated with cancer-specific mortality following disease recurrence.

Study details: Retrospective analysis of various clinicopathologic features in 331 patients (70% were male, median age at surgery 62 years) whose disease recurred after radical (n=307) or partial nephrectomies (n=24). Of the recurrences, 63 (19%) were local and 268 (81%) were distant.

Disclosures: The researchers had no relevant financial disclosures.

Source: Rieken M et al. Clinical Genitourinary Cancer (published online March 24, 2018) https://doi.org/10.1016/j.clgc.2018.03.003 .