Myelodysplastic Syndrome
News
Drugs can increase risk of MDS and AML
A class of immunosuppressive agents appear to increase the risk of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in patients...
Conference Coverage
AG-221 sparked durable responses in hematologic cancers
Key clinical point: AG-221 could shift the treatment for IDH2 mutation-positive hematologic cancers. Major finding: Fourteen of 25 patients...
Conference Coverage
Inhibitor shows promise for hematologic disorders
Photo courtesy of EHA MILAN—The IDH2 inhibitor AG-221 is well-tolerated and exhibits durable clinical activity in patients with hematologic...
News
Group finds cancer stem cells in MDS patients
Credit: NIH A new study provides “conclusive evidence” to support the existence of cancer stem cells in patients with myelodysplastic syndromes (...
News
Testing reveals abnormalities in CN-AML/MDS
Credit: NIGMS NASHVILLE—New research suggests we may need to use more sensitive methods to analyze patients with cytogenetically normal acute...
News
Monosomal karyotype, high prognostic risk score predicted transplantation failure
Major finding: Patients with a monosomal karyotype had a 49% relapse rate and a 10% 5-year overall survival rate, and those considered high or...
News
Cell-cycle inhibitor entinostat appeared to block azacitidine action
Major finding: The addition of cell-cycle inhibitor entinostat to a 10-day schedule of treatment with azacitidine led to a lower overall...
Conference Coverage
Lower-dose quizartinib diminishes QT events
Major finding: An increase in QTcF from baseline of more than 60 msec was seen in 19% of patients on quizartinib 60 mg and in 3% of those on 30 mg...
News
Drug gets orphan designation for MDS
The drug, CPI-613, targets metabolic changes that are thought to occur in many cancer cells. It has demonstrated activity and tolerability in a...
News
Despite efficacy, most patients discontinued therapy
In a multicenter trial, deferasirox reduced serum ferritin and labile plasma iron (LPI) in transfusion-dependent patients with myelodysplastic...
News
More Extensive Gene Profiling Urged in AML, MDS
Major Finding: In one study 97.3% of samples from patients with AML had mutations in 18 genes.