Pediatric Neuroblastoma
From the Journals
Genomic analysis reveals insights into pathogenesis of neuroblastoma
Researchers identified drivers of disease and potential therapeutic targets.
From the Journals
Early results ‘encouraging’ for CAR NKT cells in neuroblastoma
The CAR NKT cells localized to tumors, and one of three patients treated achieved a response.
From the Journals
Tandem transplants provide EFS edge in pediatric neuroblastoma
Patients randomized to tandem stem cell transplants after successful induction therapy had fewer events than patients assigned to single...
Conference Coverage
Trial matches pediatric cancer patients to targeted therapies
Nearly a quarter of the patients screened as part of the National Cancer Institute–Children’s Oncology Group Pediatric MATCH trial have been...
Conference Coverage
Entrectinib exhibits activity in children with solid tumors
Entrectinib produced responses in patients who had fusions or mutations in target genes.
From the Journals
Proposed neuroblastoma classification scheme hinges on telomere maintenance mechanisms
Genomic analysis showed telomere maintenance mechanisms, RAS mutations, and p53 mutations were strongly associated with outcome and other disease...
Conference Coverage
cfDNA reveals targetable mutations in pediatric neuroblastoma, sarcoma
PITTSBURGH – ‘Liquid biopsy’ of patients with genetically profiled tumors showed potentially actionable somatic mutations and copy number...
Conference Coverage
Multiple solid tumors targeted by concept CAR T
PITTSBURGH – Could this CAR T therapy become a viable option against pediatric solid tumors?