Renal Cell Carcinoma
From the Journals
SBRT controls oligometastatic RCC in majority of patients
Stereotactic body radiation therapy (SBRT) is a safe and effective treatment option for patients with oligometastatic renal cell carcinoma (RCC),...
From the Journals
TKIs feasible and effective in Brazilian population with clear cell RCC
Overall survival rates were lower than in clinical trials, likely because this real-world population had worse baseline prognoses.
From the Journals
Osteonecrosis of jaw in mRCC higher with denosumab/antiangiogenics
Of 41 patients with metastatic kidney cancer treated with denosumab and a tyrosine kinase inhibitor, 7 developed osteonecrosis of the jaw.
From the Journals
Prognostic model has clinical utility in mCRPC
The 11-variable model showed significant separation between low-risk and high-risk patients, providing useful guidance in determining...
From the Journals
PD1 mRNA may predict response to anti-PD1 monotherapy across cancer types
High levels of PD1 mRNA were significantly associated with response to anti-PD1 monotherapy for 117 patients with advanced cancers who had...
From the Journals
Patients with mRCC survive longer at high-volume centers
Survival outcomes were better for patients treated at centers caring for a mean of 20 patients per year compared with 5 or 10 per year.
From the Journals
Sunitinib for RCC: Side effects predictable, manageable, and reversible
Patients did report reduced health-related quality of life, but with the exception of diarrhea and loss of appetite, those changes were generally...
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Sunitinib alone not inferior to nephrectomy-sunitinib in metastatic RCC
Overall survival was not inferior in the sunitinib arm compared with the nephrectomy-plus-sunitinib arm in the phase 3 CARMENA trial.
From the Journals
Study sheds new light on prognostic factors in PRCC
PRCC subtypes 1 and 2 have differing histologic features and immunohistochemical profiles, but subtype does not independently predict overall...
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Hypofractionated radiation has untapped potential as RCC mets therapy
In a review of five studies of single-dose RT, 89% of patients achieved local control and less than 5% experienced severe toxicity.
From the Journals
Increasing incidence of metastatic RCC raises concerns for SREs
Investigators estimate that 85% of patients with metastatic RCC may experience SREs and related complications, with an average of more than two...