Series Editor: Arthur T. Skarin, MD, FACP, FCCP
Neuroendocrine tumors (NETs) are a rare, heterogeneous group of neoplasms that arise from neuroendocrine cells located throughout the body. These tumors are characterized by variable but most often indolent biologic behavior. They are also classically characterized by their ability to secrete peptides, resulting in distinctive hormonal syndromes. Although NETs have been considered rare, recent studies suggest that they are more common than previously suspected. An analysis of the Surveillance, Epidemiology, and End Results (SEER) database demonstrated a significant increase in the incidence of NETs over time with an age-adjusted annual incidence in the United States of 5.25 cases per 100,000 population. The increase in incidence is likely attributable to increasing awareness, improved diagnostic strategies, and possibly other undetermined environmental and genetic factors.
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