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Conditioning Regimens for MCL Compared

Biol Blood Marrow Transplant; ePub 2017 Oct 20; Tseng, et al

Publish date:: November 1, 2017

Total body irradiation- (TBI) and carmustine, etoposide, cytarabine, melphalan- (BEAM) based conditioning regimens were confirmed to be viable options for patients with mantle cell lymphoma (MCL) undergoing autologous stem cell transplant (ASCT) in a study involving 75 individuals. Participants with MCL underwent ASCT at a single institution between 2001 and 2011 with either TBI- (n=43) or BEAM-based (n=32) conditioning. Among the results:

Most patients had chemosensitive disease.
87% were transplanted in first remission.
There were no statistically significant differences in 5-year progression free and overall survival rates.
Early toxicity, non-relapse mortality, and secondary malignancies were also similar in both groups.

Citation:

Tseng Y, Stevenson P, Cassaday R, et al. Total body irradiation is safe and similarly effective to chemotherapy-only conditioning in autologous stem cell transplantation for mantle cell lymphoma patients. [Published online ahead of print October 20, 2017]. Biol Blood Marrow Transplant. doi:10.1016/j.bbmt.2017.10.029.

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