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Does This Predict Acute Pain in Children with SCD?

Am J Hematol; ePub 2018 Jan 25; Willen, et al

Publish date:

Low nocturnal hemoglobin oxygen saturation (SpO2), higher obstructive apnea-hypopnea index (OAHI), and higher oxygen desaturation index (ODI) were not linked with higher rates of acute severe pain episodes in children with sickle cell anemia, according to a multicenter prospective cohort study involving 140 individuals. Participants were a median age of ~11 years with sickle cell anemia. Investigators conducted overnight polysomnography evaluations at baseline and followed patients for median age of ~5 years. Among the results:

  • Patients with higher average nocturnal SpO2 were 10% more likely to experience pain episodes.
  • Lower SpO2 was not predictive.
  • Higher OAHI did not pass screening criteria.
  • Higher ODI was not significantly linked with higher rates of pain episodes.
Citation:

Willen S, Rodeghier M, Rosen C, DeBaun M. Sleep disordered breathing does not predict acute severe pain episodes in children with sickle cell anemia. [Published online ahead of print January 25, 2018]. Am J Hematol. doi:10.1002/ajh.25013.

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