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Familial Clustering of Multiple Myeloma

Searching for associations with discordant cancers

Publish date:: November 25, 2015

All the associations of multiple myeloma (MM) with discordant cancers are novel, suggesting that MM shares genetic susceptibility with many cancers. This according to a study of 24,137 MM patients and their family members. Researchers found:

• MM was reliably associated with relatives’ colorectal, breast, and prostate cancers; nonthyroid endocrine tumors, leukemia, and cancer of unknown primary.

• MM was also associated with subsites of bone and connective tissue tumors and of non-Hodgkin lymphoma, including lymphoplasmacytic lymphoma/Waldenstrӧm macroglobulinemia.

• The associations of MM bone and connective tissue tumors were supported by at least 2 independent results.

• MM showed a strong association in colorectal cancer families, possibly as part of an unidentified syndrome.

Citation: Frank C, Fallah M, Chen T, et al. Search for familial clustering of multiple myeloma with any cancer. [Published online ahead of print November 17, 2015]. Leukemia. doi: 10.1038/leu.2015.279.

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