Alzheimer's & Cognition
From the Journals
AHA reviews impact of aggressive LDL lowering on the brain
The risk for hemorrhagic stroke associated with statin therapy in patients without a history of cerebrovascular disease is “small and consistently...
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How does lecanemab work in Alzheimer’s?
“In our study, we looked at lecanemab and found it can block the activation of the contact system, which could be one of the reasons that it works...
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Sedentary lifestyle tied to increased dementia risk
Dementia risk was elevated whether participants were sedentary for 10 uninterrupted hours or multiple sedentary periods that totaled 10 hours over...
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Abdominal fat linked to lower brain volume in midlife
“Overall, we found that both subcutaneous and visceral fat has similar levels of negative relationships with brain volumes.”
Savvy Psychopharmacology
Abnormal sexual behaviors in frontotemporal dementia
Mr. S, age 77, is admitted to a longterm care facility due to progressive cognitive impairment and sexually inappropriate behavior.
From the Journals
Dementia diagnosis a good time to reduce polypharmacy
Time of diagnosis can be a potential inflexion point for deprescribing long-term medications with safety risks, limited benefit, or possible...
From the Journals
Few meet eligibility for newer Alzheimer’s drugs
Fewer than 10% of early Alzheimer’s patients in a real-world cohort would qualify for trials of anti–amyloid-beta monoclonal antibodies, a study...
From the Journals
‘Emerging’ biomarker may predict mild cognitive impairment years before symptoms
Low NPTX2 levels are predictive of MCI symptom onset more than 7 years in advance.
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Inhaling pleasant scents during sleep tied to a dramatic boost in cognition
“To my knowledge, that level of [memory] improvement is far greater than anything that has been reported for healthy older adults ...”
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Depression at any stage of life tied to increased dementia risk
The double risk persists regardless of when in life depression is diagnosed.
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Medicare to pay for at-home dementia care coordination
The program is voluntary and will be open to Medicare-enrolled clinicians and other providers who can assemble an interdisciplinary care team and...