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Atypical case of cutaneous MCL mimics SPTCL
The unusual case shows the importance of molecular cytogenetics and/or immunohistochemistry when making a diagnosis in panniculitis-type lymphomas...
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ctDNA predicts recurrence in nonmetastatic colorectal cancer
The sensitivity of ctDNA testing for disease recurrence was 100%, compared with 60% for CEA testing, in an observational study of 58 patients with...
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ARCHES: Enzalutamide improves mHSPC survival regardless of baseline PSA
For men with metastatic hormone-sensitive prostate cancer, enzalutamide with ADT offers longer radiographic progression-free survival compared...
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Systemic therapies are impacting melanoma’s prognostic factors
Systemic treatments have altered the disease kinetics for patients with melanoma.
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CAR T-cell therapy bb2121 performs well in phase 1 trial of refractory multiple myeloma
The objective response rate of 85% among 33 heavily pretreated patients suggests “promising efficacy.”
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Idelalisib shows long-term safety, efficacy for relapsed CLL
The long-term data confirm that the addition of idelalisib to rituximab significantly improves outcomes for patients with relapsed CLL. However,...
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Circulating tumor cells predict NSCLC survival, but clinical role uncertain
GENEVA - CTC counts of at least 5 cells per 7.5 mL were associated with reduced overall survival in a retrospective analysis involving 550...
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BWH classification system better predicts outcomes in HNCSCC
The Brigham and Women’s Hospital tumor classification system was better than the AJCC 8 in predicting metastases and death among 459 patients with...
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TTP death linked to elevated troponin and neurological signs
GLASGOW – The registry-based study showed that more than 70% of patients who presented with thrombotic thrombocytopenic purpura had neurological...
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High-dose MTX-based chemo is well tolerated in older PCNSL patients
GLASGOW – A retrospective, real-world study suggests that older, fit patients can tolerate an intensive treatment regiment for primary central...
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Monitoring, early intervention key to CAR T safety
GLASGOW – Dr. Loretta Nastoupil of the MD Anderson Cancer in Houston said that toxicity in CAR T-cell therapy “is something we don’t talk about as...
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Complementary medicine use common among patients on TKIs
GLASGOW – A survey of chronic myeloid leukemia patients taking tyrosine kinase inhibitors (TKIs) revealed that more than one-third were taking...
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PACIFIC: Patient-reported outcomes unaffected by PD-L1 expression
GENEVA – Level of programmed death-ligand 1 expression does not impact patient-reported outcomes among those...
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Survival after squamous recurrence may be unaffected by immune status
Patients who have recurrence of cutaneous squamous cell cancer of the head and neck (cSCC-HN) tend to have poor outcomes regardless of immune...
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HAVEN 4: Monthly emicizumab shows value
Emicizumab was effective as a monthly treatment for patients with hemophilia A, both with and without inhibitors, according to an ongoing phase 3...