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Osimertinib again shows strength in NSCLC with leptomeningeal metastases
GENEVA – The overall response rate was 55% for patients with NSCLC and leptomeningeal metastases receiving...
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Mouthwash shows some efficacy for oral mucositis pain
Patients undergoing head and neck radiotherapy who used mouthwash had lower pain scores, compared with placebo, but clinical thresholds weren’t...
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C3 inhibitor shows potential in PNH and AIHA
GLASGOW – Researchers presented early results from the PADDOCK and PLAUDIT trials, showing that APL-2 significantly increased hemoglobin levels...
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First-line afatinib responses encouraging across diverse population of EGFR TKI-naive patients
GENEVA – The objective response rate was 46% in an interim analysis of EGFR TKI-naive patients with locally advanced...
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Liquid biopsy falls short for isolated brain lesions in lung cancer
GENEVA – Plasma circulating tumor DNA analysis detected molecular abnormalities in almost all patients with systemic...
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Afatinib shows safety and efficacy among elderly
GENEVA – In a retrospective analysis of the GIDEON phase 3 trial involving patients with EGFR-positive NSCLC, there...
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MicroRNA-375 may be key to fibrolamellar carcinoma
Overexpression of microRNA-375 in a fibrolamellar carcinoma cell line suppressed cell migration and proliferation, which hints at therapeutic...
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Larotrectinib responses support routine NTRK gene fusion testing for lung cancer
GENEVA – Although NTRK fusions are relatively infrequent in lung cancer, a subgroup analysis demonstrates an overall...
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Pooled KEYNOTE data support pembro for elderly patients with NSCLC
GENEVA – Investigators analyzed data from 264 patients 75 years or older involved in the KEYNOTE-010, KEYNOTE-024,...
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Tumor-treating fields boost chemo for mesothelioma
GENEVA - Patients with malignant pleural mesothelioma who were treated with TTFields in combination with pemetrexed and...
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MRI predicts ALK status of NSCLC via brain lesions
GENEVA – Radiogenomic MRI signatures may be useful in identifying ALK-positive brain metastases in NSCLC, allowing...
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European NAVIGATE data support safety of electromagnetic navigation bronchoscopy
GENEVA – For lung lesion biopsy, electromagnetic navigation bronchoscopy offers high navigational success with a relatively low rate of...
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CV disease and mortality risk higher with younger age of type 2 diabetes diagnosis
In contrast, developing type 2 diabetes over the age of 80 years had little impact on risk.
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Targeting parasitic histones may improve outcomes in cerebral malaria
GLASGOW – This research could guide the development of treatment strategies for hundreds of thousands of patients each year, particularly children...
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Early data support R-BAC for post-BTKi mantle cell lymphoma
GLASGOW – The combination outperformed previously published data for other treatments in the relapsed/refractory setting.