Practical Pearls
Individualizing Care for Melanoma Patients
Melanoma is unpredictable, making patient visits and communications complicated. Following the initial diagnosis, individualized patient care is...
Sara Harcharik Perkins, MD; Kristian D. Stensland, MD; Matthew D. Galsky, MD; Shanthi Sivendran, MD, MSCR
Dr. Perkins is from the Department of Medicine, Massachusetts General Hospital, Boston. Dr. Stensland is from the Departments of Surgery and Urology, Lahey Hospital & Medical Center, Burlington, Massachusetts. Dr. Galsky is from the Departments of Urology and Medicine, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Dr. Sivendran is from the Ann B. Barshinger Cancer Institute, LG Health Physicians Hematology & Medical Oncology, Lancaster General Health, Pennsylvania.
Drs. Perkins, Stensland, and Sivendran report no conflict of interest. Dr. Galsky has received research grants from Bristol-Myers Squibb Company and Novartis Pharmaceutical Corporation and is on the advisory board for and has received research grants from Merck & Co.
Correspondence: Shanthi Sivendran, MD, MSCR, Ann B. Barshinger Cancer Institute, 2102 Harrisburg Pike, Lancaster, PA 17601 (shanthisivendran@gmail.com).
Our study also highlights the dynamic nature of the field. For example, novel vaccine therapies have demonstrated promise in the metastatic/ unresectable tumor setting, with some herpes simplex virus–based vaccines generating durable antitumor immune responses in patients with melanoma.21 Combination therapy with CTLA-4 and PD-1 inhibitors has demonstrated improved objective response rates and progression-free survival over monotherapy.22 As the status of actively recruiting trials changes on a regular basis, we encourage physicians to access ClinicalTrials.gov to find details and contact information for actively recruiting trials and results on completed trials.
Early detection and management, however, still remain our primary option for cure, and the role of community dermatologists cannot be overstated.23 Patients with stage I and stage II disease have excellent long-term survival rates, yet only 6% of all clinical trials in cutaneous melanoma have focused on patient education, disease prevention, early detection, and local management. With an increasing incidence of melanoma among an aging population, the disease burden remains of substantial concern.24 Optimizing disease prevention, appropriate screening, and early detection are critical roles for dermatologists.
Finally, our data offer some insight into accrual barriers often faced by clinical trials. Actively enrolling clinical trials cluster within major metropolitan areas, presumably with large academic medical centers; however, areas in the southwestern United States and Florida, for example, have some of the highest burden of disease, likely secondary to sun exposure and aging populations.25 Integration of community dermatologists and oncologists may decrease both actual and patient-perceived barriers to care, which requires further exploration.6
Conclusion
Melanoma incidence and disease burden is increasing, and the field of melanoma research is incredibly dynamic. Going forward, we believe dermatologists will continue to play a critical role both in primary disease prevention and detection as well as in detection of secondary treatment-related skin toxicities. ClinicalTrials.gov is an invaluable resource to keep interested parties informed, foster collaboration, identify potential barriers to success, and suggest future directions.
Melanoma is unpredictable, making patient visits and communications complicated. Following the initial diagnosis, individualized patient care is...
Melanoma has become more diverse in terms of the patients affected and the treatment course. Dr. Lorraine L. Rosamilia discusses individualized...
Melanoma was an important topic at multiple sessions of the 73rd Annual Meeting of the American Academy of Dermatology (AAD) in San Francisco,...