Drug Therapy
Newer Topical Therapies for the Treatment of Acne Vulgaris
Cutis. 2007 November;80(5):400-410
By
Del Rosso Jq
Author and Disclosure Information
Del Rosso JQ
Newer topical therapies approved by the US Food and Drug Administration (FDA) for the treatment of acne vulgaris are dapsone gel 5% and clindamycin phosphate 1.2% and tretinoin 0.025% combination gel. Both are formulated in aqueous-based gel vehicles. These newer topical acne products have been shown to be effective and safe in pivotal 12-week phase 3 trials and long-term studies completed over 12 months. This article reviews applicable pharmacokinetic, efficacy, and safety data reported with both products.