Primary Cutaneous Nodular Amyloidosis: Case Report and Review of the Literature
This article has been peer reviewed and approved by Michael Fisher, MD, Professor of Medicine, Albert Einstein College of Medicine. Review date: July 2009.
Mr. Schwendiman and Drs. Beachkofsky, Wisco, Owens, and Hodson report no conflict of interest. The authors report no discussion of off-label use. Dr. Fisher reports no conflict of interest. The staff of CCME of Albert Einstein College of Medicine and Cutis® have no conflicts of interest with commercial interest related directly or indirectly to this educational activity. Mr. Schwendiman is a medical student, Des Moines University College of Osteopathic Medicine and Surgery, Iowa. Dr. Beachkofsky is a transitional intern and Dr. Wisco is a staff dermatologist both from Wilford Hall Medical Center, Lackland Air Force Base, Texas. Dr. Owens was Assistant Program Director and currently is Program Director, San Antonio Uniformed Services Health Education Consortium Dermatology Residency, Texas. Dr. Hodson is a Mohs surgery fellow, Skin Surgery Center, Winston-Salem, North Carolina. The opinions expressed in this article are those of the authors and do not represent the viewpoints of the US Air Force, US Army, or US Department of Defense.
Mark N. Schwendiman, MS-IV; Thomas M. Beachkofsky, MD; Oliver J. Wisco, DO; Nicole M. Owens, MD; Darryl S. Hodson, MD
Primary cutaneous nodular amyloidosis (PCNA) is a rare form of primary cutaneous amyloidosis. It presents as waxy yellow-red nodules that are located preferentially on the lower extremities, face, scalp, and genitals. Recognition of this condition is of particular importance, as primary systemic amyloidosis can have a similar cutaneous presentation. We report a case of PCNA in a 52-year-old woman with systemic lupus erythematosus (SLE) and Sjögren syndrome (SS). We discuss the need to evaluate for systemic disease and provide a concise review of the literature focusing on clinical presentation, disease associations, and management.