Basal Cell Carcinoma: Hedgehog Pathway Inhibitors and Beyond

An evolving theme in cutaneous oncology is targeted therapy. Blockade of the hedgehog signaling pathway has been a breakthrough in the management of patients with advanced basal cell carcinoma (BCC). Although promising results have been reported, recurrence and evolution of new tumors via circumvention of traditional pathways has occurred. Dr. Brooke Walls reviews the hedgehog signaling pathway, tumorigenesis, and novel strategies for the development of next-generation drugs.