Rare Diseases
Feature
Biosimilars and patients: Discussions should address safety, cost, and anxiety about change
Physicians can respond to pushback from patients on switching to a biosimilar by offering resources and discussing options for both biosimilar and...
From the Journals
CT results in myositis inform cancer screening strategies
Patients with the autoantibody anti–TIF1-gamma had the highest diagnostic yield, while patients under 40 years old had a high frequency of false...
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Phase 3 prurigo nodularis trial shows positive results for nemolizumab
“The use of topical steroids was not allowed in this trial,” Dr. Shawn G. Kwatra said.
From the Journals
Autoantibodies signal reduced cancer risk in dermatomyositis
In patients with dermatomyositis positive for anti–TIF1-gamma autoantibodies, the presence of anti-CCAR1 autoantibodies indicate normal rather...
From the Journals
Antibiotics and SJS/TEN: Study provides global prevalence
Sulfonamides responsible for the highest proportion of antibiotic-triggered Stevens-Johnson syndrome and toxic epidermal necrolysis.
Make the Diagnosis
A White male presented with a 1½-year history of a progressive hypoesthetic annular, hyperpigmented plaque on the upper arm
A patient presents with a subtle, solitary 4-cm annular skin-colored thin plaque on his left posterior upper arm.
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Topical gene therapy heals dystrophic epidermolysis bullosa wounds
“The results prove that B-VEC, the first topical in vivo gene therapy to reach late-stage development, can heal DEB,” one of the investigators...
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Expert gives tips on less-discussed dermatologic diseases
These diseases are important not to miss and can “also be quite challenging when we think about their management.”
From the Journals
VEXAS syndrome: More common, variable, and severe than expected
A large U.S. analysis found that this newly discovered genetic disease has a estimated prevalence of 1 in 4,269 in men older than 50.
Feature
Mastocytosis: Rare, underdiagnosed, potentially fatal
This often-missed myeloid neoplasm could be deadly and deserves greater attention, experts say.
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New PDT therapy for CTCL to be reviewed by FDA
The treatment has received orphan drug and fast track designations from the FDA, and orphan designation from the European Medicines Agency,...