Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Practical Measures of Ruxolitinib’s Clinical Benefit

Clin Lymphoma Myeloma Leuk; ePub 2017 May 12; Miller, et al

Publish date:: May 28, 2017

Ruxolitinib’s benefit in patients with myelofibrosis can be assessed using a number of methods that are easily accessed in the community setting, according to a post hoc analysis of data from COMFORT-I trial involving 150 individuals.

Investigators evaluated changes over 12 weeks in spleen size, patient-reported outcomes, body weight, and serum albumin levels in 5 ruxolitinib-treated subgroups divided based on spleen length. Among the results:

Ruxolitinib was linked with improved spleen volume in all subgroups, including those with worsening spleen length.
Body weight and serum albumin levels also improved.
Greater reductions in spleen length were linked with prolonged overall survival.

Citation:

Miller C, Komrokji R, Mesa R, Sun W, Montgomery M, Verstovsek S. Practical measures of clinical benefit with ruxolitinib therapy: An exploratory analysis of COMFORT-I. [Published online ahead of print May 12, 2017]. Clin Lymphoma Myeloma Leuk. doi:10.1016/j.clml.2017.05.015.

This Week's Must Reads

Consider potential cognitive complications prior to androgen deprivation therapy,

Diabetes raises risk of prostate cancer mortality in obese men,

Salivation inhibition fails to reduce radioiodine toxicity in prostate cancer,

Highest positive surgical margin predicts poor survival after prostatectomy,

Young minority men are underinformed about prostate cancer screening,

Must Reads in Hematologic Malignancies

Long-term ibrutinib data in older patients, Barr PM et al. Haematologica. 2018;103(9):1502-10

Prognostic Score System for Patients with PMF, J Clin Oncol; ePub 2017 Dec 9; Gugliemelli, et al

These Patients Are More Apt to Be Depressed, Ann Hematol; ePub 2017 Dec 7; Shreders, et al

Survival Length Shortest in These Patients with MF, Eur J Haematol; ePub 2017 Dec 11; Masarova, et al

The Value of Ruxolitinib Before and After AlloSCT, Blood; ePub 2017 Dec 7; Poulose, Malysz, et al