Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Consider potential cognitive complications prior to androgen deprivation therapy

Key clinical point: Androgen deprivation therapy has been known to have a negative effect on cognitive function, however, data are conflicting and an association between ADT and cognitive dysfunction remains unconfirmed.

Major finding: In a longitudinal study of 2,974 men, bioavailable testosterone was not associated with increased dementia risk, but higher levels of bioavailable estradiol were significant predictors of Alzheimer’s disease.

Study details: The data come from a review of recent studies involving androgen deprivation therapy to treat prostate cancer.

Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.


Shim M et al. Prostate Int. 2021 Mar 9. doi: 10.1016/j.prnil.2021.02.002.