Key clinical point: Fasting blood glucose (FBG) variability was significantly associated with an increased risk of colorectal cancer (CRC) in healthy population without overt diabetes.
Major finding: Overall, CRC incidence during the follow-up period was 116.7 per 100,000 person-years. The highest vs lowest quintile of standard deviation of FBG showed a significantly higher risk of incident CRC (adjusted hazard ratio, 1.19; 95% confidence interval, 1.07-1.32) with each increase in standard deviation quintile being significantly associated with an increased risk of CRC ( P for trend = .001 ).
Study details: Findings are from an analysis of 246,241 healthy subjects without overt diabetes who underwent general health screening at least once between 2002 and 2003.
Disclosures: The study was funded by National Research Foundation of Korea grant funded by the Korea government. The authors declared no conflict of interests.
Source: Jun H et al. Gut Liver. 2021 Oct 1. doi: 10.5009/gnl210048 .