Key clinical point: Higher genetic susceptibility to breast cancer (BC) is associated with an increased risk for overall thyroid cancer; however, this association is not valid in case of triple-negative BC (TNBC) and thyroid cancer.
Major finding: The risk for thyroid cancer was significantly elevated in patients with BC (odds ratio 1.135; P = .038); however, no causal link was observed between TNBC and thyroid cancer (OR 0.817; P = .177).
Study details: Findings are from a two-sample mendelian randomization analysis including 133,384 patients with BC and 113,789 BC-free control individuals.
Disclosures: This study was supported by funding from the National Natural Science Foundation of China and other sources. The authors declared no conflicts of interest.
Source: Tan H et al. Association between breast cancer and thyroid cancer risk: A two-sample Mendelian randomization study. Front Endocrinol (Lausanne). 2023;14:1138149 (May 23). doi: 10.3389/fendo.2023.1138149