Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Can web tools replace pharmacokinetic analysis in hemophilia A?

Nagao A et al. Thromb Res. 2019 Jan;173:79-84

Key clinical point: Online apps designed to help generate individualized pharmacokinetic profiles supported changes in hemophilia A prophylaxis.

Major finding: Adherence stayed the same or improved in patients whose prophylaxis regimens were changed based on the tool results, while bleeding rates improved for specific patient subsets.

Study details: Prospective study including 39 patients receiving hemophilia A prophylaxis.

Disclosures: Study authors reported disclosures related to Shire, Bayer, Pfizer, Novo Nordisk, CSL Behring, and others.

Read the article here.

Citation:

Nagao A et al. Thromb Res. 2019 Jan;173:79-84.