Key clinical point: The risk for second primary breast cancer (SPBC) increased annually by 9.2% in women and 5.4% in men from 1994 to 2015. The incidence also increased substantially among cancer survivors.

Major finding: The average annual percentage change in SPBC incidence was 9.2% (95% confidence interval [CI], 8.0%-10.4%) for women and 5.4% (95% CI, 3.4%-7.5%) for men. Compared with the general population, the risk for SPBC after previous malignancy increased by 35% in women and 16% in men.

Study details: The data come from an analysis of the Surveillance, Epidemiology, and End Results database (1994-2015).

Disclosures: No funding received. The authors declared no conflicts of interest.