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This May Be Underrecognized in Allogenic HSCT Patients
Clin Lymphoma Myeloma Leuk; ePub 2017 Jun 28; Gazourian, et al
Pulmonary manifestations of chronic graft versus host disease (GVHD) were under-recognized in people receiving allogeneic hematopoietic stem cell transplantation (HSCT) in a study involving 35 individuals.
Investigators analyzed autopsy results of patients who underwent allogeneic HSCT at a single institution and died of any cause. A pathologist who did not know the autopsy results looked for presence of pulmonary GVHD.
Airway disease, vascular disease, and interstitial disease were all clinically under-recognized, compared with pathological findings. Varying degrees of pathological changes were detected as follows:
- ~3 in every 10 patients had bronchiolitis obliterans.
- ~One-third had pulmonary veno-occlusive disease.
Gazourian L, Spring L, Meserve E, Kristin Seeger, et al. Pulmonary clinicopathological correlation following allogeneic hematopoietic stem cell transplantation: An autopsy series. [Published online ahead of print June 28, 2017]. Clin Lymphoma Myeloma Leuk. doi:10.1016/j.bbmt.2017.06.009.