Clinical Edge Journal Scan

Having migraine increases the risk of developing neovascular AMD


Key clinical point: Patients with migraine present with a 20% higher risk of developing neovascular age-related macular degeneration (AMD) compared with individuals without migraine.

Main finding: A significantly higher proportion of patients with neovascular AMD vs. control individuals had migraine before the index date (6.1% vs. 4.9%; P < .001), with an adjusted (for age, sex, monthly income, geographic location, urbanization, hyperlipidemia, diabetes, coronary heart disease, hypertension, and cataract surgery) odds ratio of 1.201 ( P < .001).

Study details: This nationwide, population-based study included 20,333 patients aged 40 years or older diagnosed with neovascular AMD in at least 2 claims, with the first diagnosis date defined as the index date. They were propensity score-matched (1:4) with 81,332 nonneovascular AMD control individuals.

Disclosures: No source of funding was declared. None of the authors identified any conflicts of interest.

Source: Kuang TM et al. Sci Rep. 2022;12:1792 (Feb 2). Doi: 10.1038/s41598-022-05638-5

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