Wake-up call
Study participants received 1 point for each item/domain, with a sum score of 0 or 1 classified as “socially isolated” and 2 or more points considered “not socially isolated.” They were classified as having probable dementia based either on self-report or lower-than-mean performance in 2 or more cognitive domains, or a score indicating probable dementia on the AD8 Dementia Screening Interview.
Covariates included demographic factors, education, and health factors. Mean follow-up was 5.1 years.
Results showed close to one-quarter (23.3%) of the study population was classified as socially isolated, with one-fifth (21.1%) developing dementia by the end of the follow-up period.
Compared with non-isolated older adults, those who were socially isolated were more likely to develop dementia during the follow-up period (19.6% vs. 25.9%, respectively).
After adjusting for demographic factors, social isolation was significantly associated with a higher risk for incident dementia (hazard ratio, 1.33; 95% confidence interval, 1.13-1.56). This association persisted after further adjustment for health factors (HR, 1.27; 95% CI, 1.08-1.49). Race and ethnicity had no bearing on the association.
In addition to the association between social isolation and dementia, the researchers also estimated the cause-specific hazard of death before dementia and found that, overall, 18% of participants died prior to dementia over the follow-up period. In particular, the social isolation–associated cause-specific HR of death before dementia was 1.28 (95% CI, 1.2-1.5).
Dr. Cudjoe noted that the mechanism behind the association between social isolation and dementia in this population needs further study. Still, he hopes that the findings will “serve as a wake-up call for all of us to be more thoughtful of the role of social connections on our cognitive health.”
Clinicians “should be thinking about and assessing the presence or absence of social connections in their patients,” Dr. Cudjoe added.
‘Instrumental role’
Commenting on the study, Nicole Purcell, DO, neurologist and senior director of clinical practice at the Alzheimer’s Association, said the study “contributes to the growing body of evidence that finds social isolation is a serious public health risk for many seniors living in the United States, increasing their risk for dementia and other serious mental conditions.”
Dr. Purcell, who was not involved with the study, added that “health care systems and medical professionals can play an instrumental role in identifying individuals at risk for social isolation.”
She noted that for those experiencing social isolation, “interaction with health care providers may be one of the few opportunities those individuals have for social engagement, [so] using these interactions to identify individuals at risk for social isolation and referring them to local resources and groups that promote engagement, well-being, and access to senior services may help decrease dementia risk for vulnerable seniors.”
Dr. Purcell added that the Alzheimer’s Association offers early-stage programs throughout the country, including support groups, education, art, music, and other socially engaging activities.
The study was funded by the National Institute on Aging, National Institute on Minority Health and Health Disparities, and Secunda Family Foundation. The investigators and Dr. Purcell have reported no relevant financial relationships.
A version of this article first appeared on Medscape.com.