Movement Disorders
Literature Review
Blood biomarker may predict Parkinson’s disease progression
Neurofilament light chain levels are heightened in Parkinson’s disease and may aid diagnosis, but it is limited by low specificity.
Literature Review
Can DBS in early Parkinson’s disease reduce disease progression?
Compared with standard treatment, DBS plus drug therapy appears to reduce the need for polypharmacy.
Literature Review
Circadian rhythm changes linked to future Parkinson’s disease risk
Circadian rhythmicity could be a promising intervention target and may open new opportunities for the prevention and management of Parkinson’s...
Literature Review
Huntington’s disease biomarkers appear 24 years before clinical symptoms
Early signs of neurodegeneration despite normal brain function detected in young adult carriers of the Huntington’s disease gene.
Conference Coverage
Nilotinib is safe in moderate and advanced Parkinson’s disease
Although the drug is safe and tolerable, it penetrates the brain poorly and does not change levels of dopamine or its metabolites.
News
FDA approves apomorphine sublingual film for ‘off’ episodes in Parkinson’s disease
This marks the first approval for a sublingual therapy for this indication.
Conference Coverage
GI symptoms in Parkinson’s disease correlate with less microbial diversity
Eight of the 15 gastrointestinal symptoms assessed were significantly increased in patients with Parkinson’s disease, relative to controls.
Literature Review
Researchers identify a cause of L-DOPA–induced dyskinesia in Parkinson’s disease
The identification of a protein that contributes to abnormal involuntary movements may enable the development of improved treatments for Parkinson...
Conference Coverage
Targeting gut bacteria may improve levodopa uptake
Differences in metabolism of levodopa between patients with Parkinson’s disease may be caused by variations in abundance of the gut bacteria ...
Conference Coverage
Expert says progress in gut-brain research requires an open mind
“What happens in [the] vagus doesn’t just stay in vagus, but will actually affect our emotions in different ways,” Dr. Cryan said.
Literature Review
As costs for neurologic drugs rise, adherence to therapy drops
In patients with Parkinson’s disease, dementia, and neuropathy, higher out-of-pocket drug prices were associated with lower adherence for common...