Carol Lim, MD, MPH Fellow in Public and Community Psychiatry Massachusetts General Hospital Harvard Medical School Boston, Massachusetts
Manjola U. Van Alphen, MD, PhD, MBA Chief Medical Officer North Suffolk Mental Health Association Instructor in Psychiatry MGH Schizophrenia Clinical and Research Program Harvard Medical School Boston, Massachusetts
Oliver Freudenreich, MD, FACLP Co-Director MGH Schizophrenia Clinical and Research Program Director MGH Fellowship in Public and Community Psychiatry Massachusetts General Hospital Associate Professor of Psychiatry Harvard Medical School Boston, Massachusetts
Disclosures Dr. Freudenreich has received research grants (to institution) and consultant honoraria (advisory board) from Janssen (area: schizophrenia, long-acting injectable antipsychotics). Drs. Lim and Van Alphen report no financial relationships with any companies whose products are mentioned in this article, or with manufacturers of competing products.
Managing overvalued ideas. Psychiatrists are also well-versed in having discussions with patients who hold irrational beliefs (psychosis) or overvalued ideas. For example, psychiatrists frequently manage anorexia nervosa and hypochondria, which are rooted in overvalued ideas.7 While psychiatrists may not be able to directly confront the overvalued ideas, they can work around such ideas while waiting for more flexible moments. Similarly, managing patients with intense emotional commitment7 to commonly held anti-vaccination ideas may not be much different. Psychiatrists can work around resistance until patients may be less strongly attached to those overvalued ideas in instances when other techniques, such as motivational interviewing and nudging, may be more effective.
Managing uncertainty.Psychiatrists are experts in managing “not knowing” and uncertainty. Due to their medical scientific training, they are familiar with the process of science, and how understanding changes through trial and error. In contrast, most patients usually only see the end product (ie, a drug comes to market). Discussions with patients that acknowledge uncertainty and emphasize that changes in what is known are expected and appropriate as scientific knowledge evolves could help preempt skepticism when messages are updated.
Why do patients with SMI need more help?
SMI as a high-risk group. Patients with SMI are part of a “tragic” epidemiologic triad of agent-host-environment15 that places them at remarkably elevated risk for COVID-19 infection and more serious complications and death when infected.1 After age, a diagnosis of a schizophrenia spectrum disorder is the second largest predictor of mortality from COVID-19, with a 2.7-fold increase in mortality.22 This is how the elements of the triad come together: SARS-Cov-2 is a highly infectious agent affecting individuals who are vulnerable hosts because of their high frequency of medical comorbidities, including cardiovascular disease, type 2 diabetes, and respiratory tract diseases, which are all risk factors for worse outcomes due to COVID-19.23 In addition, SMI is associated with socioeconomic risk factors for SARS-Cov-2 infection, including poverty, homelessness, and crowded settings such as jails, group homes, hospitals, and shelters, which constitute ideal environments for high transmission of the virus.
Structural barriers to vaccination.Studies have suggested lower rates of vaccination among people with SMI for various other infectious diseases compared with the general population.12 For example, in 1 outpatient mental health setting, influenza vaccination rates were 24% to 28%, which was lower than the national vaccination rate of 40.9% for the same influenza season (2010 to 2011).24 More recently, a study in Israel examining the COVID-19 vaccination rate among >25,000 patients with schizophrenia suggested under-vaccination of this cohort. The results showed that the odds of getting the COVID-19 vaccination were significantly lower in the schizophrenia group compared with the general population (odds ratio = 0.80, 95% CI: 0.77 to 0.83).25
Patients with SMI encounter considerable system-level barriers to vaccinations in general, such as reduced access to health care due to cost and a lack of transportation,12 the digital divide given their reduced access to the internet and computers for information and scheduling,26 and lack of vaccination recommendations from their PCPs.12 Studies have also shown that patients with SMI often receive suboptimal medical care because of stigmatization and discrimination.27 They also have lower rates of preventive care utilization, seeking medical services only in times of crisis and seeking mental health services more often than physical health care.28-30