Key clinical point: Obesity, anxiety, depression, and illness perception at baseline were associated with treatment outcomes, pain, and fatigue in patients with rheumatoid arthritis (RA).
Major finding: At 12 months , obesity vs. normal weight was associated with a lower likelihood of remission (adjusted odds ratio [aOR], 0.33; P=.005). Obesity and illness perception were significantly associated with pain (aOR, 8.16; P = .002 and aOR, 0.62; P < .001, respectively) and fatigue (aOR, 5.66; P = .049 and aOR, 0.51; P = .001, respectively) with patients with severe vs. no a nxiety having higher pain (aOR, 9.60; P = .010) and those with severe (aOR, 17.07; P < .001) and moderate (aOR, 10.13; P = .001) depression having higher fatigue .
Study details: This secondary analysis of the TITRATE trial included 335 patients with RA treated with intensive management (n=168) or standard care (n=167).
Disclosures: This study was funded by the National Institute for Health Research. E Nikiphorou received speaker fees and served on advisory boards for various sources. Other authors declared no competing interest.
Source: Lee SY et al. Arthritis Res Ther. 2021 Nov 4. doi: 10.1186/s13075-021-02653-1 .