AML
News
Normal enzyme aids mutated FLT3 to fuel AML
Results of preclinical research suggest the wild-type version of SYK pairs with mutated FLT3 to promote progression of acute myelogenous leukemia...
News
Methylation patterns can predict survival in AML, team says
Credit: Lance Liotta Researchers have found evidence to suggest that methylation patterns in hematopoietic stem cells (HSCs) can be used to...
News
Mouse model provides new insight into AML
Studies have suggested that mutations in isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2) are present in approximately 20% of all acute myeloid...
News
Mutation could be target for MDS/AML treatment
Scientists have found evidence to suggest that a genetic alteration in osteoblasts can induce acute myeloid leukemia (AML). And this provides a...
News
AML scoring system could optimize treatment
Credit: NIGMS A scoring system that combines genetic and epigenetic changes could help guide therapy for acute myeloid leukemia (AML), according...
Conference Coverage
Lower-dose quizartinib diminishes QT events
Major finding: An increase in QTcF from baseline of more than 60 msec was seen in 19% of patients on quizartinib 60 mg and in 3% of those on 30 mg...
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FDA provides steps to obtain ponatinib following suspension
News
Cord blood transplants improve juvenile myelomonocytic leukemia survival
Major finding: Children aged younger than 1.4 years at diagnosis had significantly better disease-free survival rates (HR, 0.42), while those who...
News
More Extensive Gene Profiling Urged in AML, MDS
Major Finding: In one study 97.3% of samples from patients with AML had mutations in 18 genes.
News
Brd4: Potential new target in AML
“The drug candidate not only displays remarkable anti-leukemia activity in aggressive disease models and against cells derived from patients with...