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Sepsis Incidence in Patients with AML Evaluated
Clin Lymphoma Myeloma Leuk; ePub 2017 Jul 25; Malik, et al
Patients with acute myeloid leukemia (AML) tend to have higher rates of sepsis and overall mortality, according to a population-based cohort study involving more than 2 million individuals. Participants were discharged from Texas hospitals in 2011. Investigators looked at sepsis incidence and mortality rates. Among the results:
- 0.25% of patients had an AML diagnosis.
- 16% of patients with AML had sepsis, vs 4% of those without AML.
- Sepsis was linked with both pneumonia and acute renal failure in ~one-third of patients with AML.
- It was linked with hematological dysfunctions in 29%.
- Median length of stay for patients with AML was 13 days.
- Nearly three-fourths were admitted to the ICU.
- Median hospital charges were ~$120,000.
- Among in-hospital deaths due to sepsis, mortality was 30% in patients with AML, vs 21% in those without AML.
Citation:
Malik I, Cardenas-Turanzas M, Gaeta S, et al. Sepsis and acute myeloid leukemia: A population level study of comparative outcomes of patients discharged from Texas hospitals. [Published online ahead of print July 25, 2017]. Clin Lymphoma Myeloma Leuk. doi:10.1016/j.clml.2017.07.009.