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Radiation Therapy After R0 Resection for NSCLC
Ann Surg Oncol; ePub 2017 Feb 2; Pezzi, et al
Radiotherapy was independently linked with worse survival following R0 resection of stage I–II non-small cell lung cancer (NSCLC) in an analysis involving nearly 200,000 individuals. Additionally, it was found to be administered mostly in community cancer programs.
Participants were from the National Cancer Database from 2004 to 2014. Investigators looked at the link between receiving radiation as part of their initial treatment and overall survival. Among the results:
- ~4,600 patients received radiation at a median dose of 55 Gy.
- Treatment at a community cancer program, sublobectomy, tumor size of 3 to 7 cm, and pN1/Nx were linked with radiation therapy.
- Patients receiving radiation survived ~46 months, vs ~78 months in those who did not receive such.
- Those in the irradiated group experienced a 31% increased mortality risk after propensity score matching.
Pezzi T, Mohamed A, Fuller C, et al. Radiation therapy is independently associated with worse survival after R0-resection for stage I–II non-small cell lung cancer: An analysis of the National Cancer Data Base. [Published online ahead of print February 2, 2017]. Ann Surg Oncol. doi:10.1245/s10434-017-5786-6.