Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Prognostic Indicator for T-Cell Prolymphocytic Leukemia
Am J Hematol; ePub 2017 Feb 27; Hu, et al
People with T-cell prolymphocytic leukemia (T-PLL) are apt to have a complex karyotype that predicts poor prognosis, according to a study involving 97 individuals. This is especially true in patients with ≥5 cytogenetic aberrations.
Participants—all of whom had T-PLL—were a median of 63 years of age. Investigators looked at links between cytogenetic abnormalities and outcomes. Among the results:
- 27 patients had a normal karyotype, 1 had 2 chromosomal aberrations, and the remainder had a complex karyotype.
- Patients with complex karyotype had worse overall survival than those with normal karyotype.
- The most common aberrations in the complex group involved 14q and 8q.
- Overall survival was nearly 1 year in patients with ≥5 aberrations; it was almost 2 years in those with <5 aberrations.
- Fluorescence in situ hybridization for TCL1 resulted in rearrangement in 8/10 normal cases and 16/17 complex cases.
- Stem cell transplantation did not improve overall survival in any group.
Citation:
Hu Z, Medeiros L, Fang L, et al. Prognostic significance of cytogenetic abnormalities in T-cell prolymphocytic leukemia. [Published online ahead of print February 27, 2017]. Am J Hematol. doi:10.1002/ajh.24679.